Ecosystem
Who's Building
These are the organizations already working toward the plan's priorities. If you're building something here, or know an organization not listed, please reach out.
biotech
For-profit gene synthesis screening and KYC verification provider
Formerly Panoplia Labs. Runs in-person wet-lab experiments measuring how frontier AI changes what people can do in biology: including the largest AIxBio randomized trial to date (2026), co-developed ABC-Bench with SecureBio, and runs wet-lab studies informing synthesis governance.
Hardware engineering firm applying physical sciences to biosecurity: automated RNA vaccine production with the University of Sheffield, next-generation respiratory PPE with Oxford, and building-scale biodefense systems with RAND. Also builds hardware for AI security (flexHEG).
field-building
AI-safety nonprofit running weekend research hackathons; its April 2026 AIxBio Hackathon (595 sign-ups, co-run with BlueDot and the Cambridge Biosecurity Hub) ran tracks on DNA screening, pandemic early warning, AI biosecurity tools, and benchtop synthesizer security.
UK Advanced Research and Invention Agency: funds programmable-biology and pandemic-resilience moonshots
US Advanced Research Projects Agency for Health: funds breakthrough health technologies including pandemic countermeasures
Biomedical Advanced Research and Development Authority: U.S. agency funding medical countermeasure development and stockpiling
biotech
Public molecular diagnostics company building quantitative DNA/RNA testing platforms across prenatal, oncology, and infectious disease: a candidate platform for rapid novel-pathogen test scale-up.
Bioeconomy Information Sharing and Analysis Center: threat intelligence sharing for biological sector
biotech
Wastewater epidemiology and pathogen surveillance platform
mRNA vaccine pioneer developing infectious disease and pandemic response platforms
Advocacy organization pushing for independent oversight of high-risk pathogen research
Public benefit corporation (Research Access Systems) building a credentialing service that AI labs, bio-tool developers, and synthesis providers use to vet who gets access to powerful biological capabilities. In pilot; funded by Sentinel Bio.
Commission of former senior US officials producing biodefense policy recommendations (National Blueprint for Biodefense, Apollo Program for Biodefense); an initiative within the Atlantic Council's Scowcroft Center since September 2025.
field-building
Runs the field's largest entry-level biosecurity course: a free 30-hour facilitated curriculum covering prevention, detection, response, and dual-use governance, with rapid and career-transition grants for graduates.
Biosecurity nonprofit conducting research, regranting, and direct program work on pandemic PPE, far-UVC germicidal technology, built environment biohardening, and biosecurity field-building.
Genomics research institute advancing pathogen sequencing, surveillance tools, and diagnostic platforms
research
Research center focused on pandemic preparedness, surveillance, and built environment interventions
U.S. Center for AI Standards and Innovation (NIST): evaluates frontier AI capabilities against biosecurity, cybersecurity, and chemical weapons risks
field-building
Biosecurity-only talent hub in Cambridge, UK running a seven-week Pandemic Prevention Fellowship, co-running the AIxBio Research Fellowship with ERA, operating SPAR's biosecurity stream, and hosting an annual AIxBio Symposium.
field-building
Cambridge Boston Alignment Initiative: its ten-week, in-person AIxBiosecurity Research Fellowship (first cohort October 2026) matches funded fellows with mentors from RAND, Active Site, SecureBio AI, and Harvard on evaluations, safeguards, biosurveillance, and synthesis screening.
UK-based policy organization focused on catastrophic and existential risk including biorisk
Coalition for Epidemic Preparedness Innovations: funds and coordinates vaccine and countermeasure development
regranting
Multi-donor philanthropic fund (formerly Open Philanthropy): major funder of biosecurity, AI safety, and pandemic preparedness
Policy organization addressing security dimensions of biological and other strategic risks
Georgetown Center for Security and Emerging Technology: policy research on AI-biosecurity intersections
DARPA's Biological Technologies Office: funds and coordinates advanced biotechnology programs for national security, including biosurveillance, medical countermeasures, and synthetic biology research.
Engineering Biology Research Consortium: responsible innovation in synthetic biology
field-building
Runs the fully funded ten-week AIxBio Research Fellowship in Cambridge, UK with the Cambridge Biosecurity Hub: fellows test biological safeguards for AI models and strengthen synthesis screening, with strong projects leading to research scholar positions.
regranting
Philanthropic advisor and fund sponsor: supports biosecurity through its Global Catastrophic Risks Fund with grants to IBBIS, Blueprint Biosecurity, and related work
Research institute developing function-based DNA synthesis screening that detects hazardous function rather than sequence similarity, and evaluating AI protein-design risk. Funded by Sentinel Bio; since June 2026 also regrants through its own RFP.
ai
Industry-led body for frontier AI safety. Operates a Biology working group focused on bio-AI safeguards, best-practice frameworks, and cross-provider information sharing among frontier model developers.
Organization focused on reducing existential risk from advanced technologies including biotechnology
regranting
Major global health funder backing vaccine development, diagnostics, and disease surveillance worldwide
Public-private alliance financing vaccine access and outbreak response stockpiles for lower-income countries
Impact investment fund focused on global health innovation
WHO Global Outbreak Alert and Response Network: deploys international teams to verify and respond to outbreaks
research
Research center on AI governance with work on dual-use biological capabilities
Biosafety and biosecurity risk analysis consultancy (now part of Deloitte): dual-use research and AI-bio risk assessments
Formerly ProEquip. Builds respiratory protection and stockpile readiness for critical-infrastructure workers, organized as Bio Threat, Bio Command, and Bio Protection capability areas.
research
Research program on indoor air quality and pathogen-resistant building design
EU Health Emergency Preparedness and Response Authority: horizon scanning, medical countermeasure R&D, and stockpiling for pandemic and CBRN threats in Europe
regranting
William & Flora Hewlett Foundation: Special Projects grantmaking at the intersection of national security, AI, and biosecurity
field-building
Places fully funded emerging-technology fellows, including biosecurity specialists, in federal agencies, congressional offices, and DC think tanks for twelve-month renewable terms; funded by Coefficient Giving and Sentinel Bio among others.
International Biosecurity and Biosafety Initiative for Science: standards and verification for synthesis screening and KYC
International Federation of Biosafety Associations: global biosafety certification and capacity building
field-building
Synthetic-biology competition whose Responsibility Program puts roughly 400 teams and 8,000+ students a year through biosafety and biosecurity review, runs an annual Responsibility Conference, and funds safety-and-security grants.
International Gene Synthesis Consortium: industry screening standards body
Professional association advancing UV technology including far-UVC for pathogen control
research
Research and policy center focused on health security and biosecurity preparedness
Venture-backed bio data company whose Latch Biosecurity unit publishes the BioSecBench AI-safety benchmarks (Function, Surveillance, Refusal), runs pre-deployment audits and red-teaming for frontier labs, and: via its June 2026 acquisition of TwentyTwo, sells agentic customer screening and function-based sequence screening to synthesis providers.
Philanthropic advisor directing major donors toward catastrophic biorisk reduction and AI-bio safeguards
CRISPR platform company whose detection technology underpins rapid molecular diagnostics; primary focus has shifted to in vivo gene-editing therapeutics.
University of Chicago and Dartmouth initiative designing advance market commitments and pull incentives that accelerate vaccines, diagnostics, and other underprovided innovations
field-building
AI-safety research training program (631 alumni since 2021) whose dedicated Biosecurity track launched Autumn 2026: twelve-week mentored fellowships spanning detection, countermeasures, AI for synthesis screening, physical biodefense, and AIxBio red-teaming.
Funding dialogues and policy development on mirror biology risks
Federally funded R&D center supporting biosecurity technical standards
mRNA platform vaccine developer with pandemic preparedness capabilities
Open-source pathogen genomic surveillance platform powering real-time outbreak tracking worldwide
US National Institutes of Health: largest public funder of biomedical research including infectious disease countermeasures
Protein nanoparticle vaccine developer with the Matrix-M adjuvant platform; partners out assets including its Sanofi-commercialized COVID-19 vaccine
National Security Commission on Emerging Biotechnology: delivered its 2025 report to Congress and continues advancing its biotech security recommendations through 2026
Nuclear Threat Initiative biosecurity program: policy, coalition-building, and threat reduction
Advocacy organization advancing challenge trials and pandemic preparedness
Open-source respiratory protection hardware: low-cost particle counters (OpenCPC) and respirators (OpenRespirator) for individuals, health systems, and governments
field-building
Biosecurity-only research training group running part-time remote project cycles with partner organizations (51 researchers across 14 projects in 2024); spun out the Biosecurity Forecasting Group in 2025.
Global health nonprofit advancing equitable access to vaccines, diagnostics, and drugs
regranting
Foundation backing a 15-year, $200M global pandemic prevention program, including the Pandemic Compensation Initiative and innovative pandemic financing
biotech
Biosecurity infrastructure company spun out of Ginkgo Bioworks in April 2026 with a $60M growth round. Runs traveler genomic surveillance at eight international airports plus wastewater and hospital nodes across the US, Africa, the Middle East, Ukraine, and Georgia.
Global pharmaceutical company with proven pandemic vaccine and antiviral development and manufacturing scale
PHC Global delivers integrated, AI-driven biological threat intelligence to support real-time decision making in complex operational environments. Built for defense, public safety, & America’s leading commercial firms.
field-building
Fellowship operator whose Frontier Biodefense Fellowship (first cohort London, August-October 2026, 20+ fellows) trains researchers on PPE for catastrophic threats, biohardening, and pathogen-agnostic detection with mentors from Blueprint Biosecurity, SecureBio, and CLTR.
India-based mRNA vaccine company using machine-learning-driven design to build low-cost, broadly protective vaccines and rapid-response capability against novel pathogens
Policy research organization whose biosecurity work sits in its Center on AI, Security, and Technology (CAST), covering AIxBio misuse evaluation and disruption, bioresilience, and mirror biology.
Resilience Action Network International, formerly Pandemic Action Network: coordinates advocacy coalitions across pandemics, biosecurity, finance, and climate; fiscally sponsored by Panorama Global.
biotech
Biotechnology company focused on rapid countermeasure development
Automated know-your-customer screening for DNA synthesis providers, cloud labs, and CROs: sanctions checks, identity verification, and sequence screening that distinguish legitimate researchers from bad actors before orders ship.
regranting
Nonprofit that stewards the Bio Action Plan and acts as a clearinghouse for the biosecurity field, connecting philanthropists, scientists, and policymakers so funding reaches the most important gaps.
Nonprofit working to protect society from catastrophic pandemics. Develops AI biosecurity evaluations (VCT, ABC-Bench, ABLE) for frontier model safety, and operates SecureBio Detection / CASPER: a national metagenomic wastewater surveillance network for early pathogen warning.
Free, open-source DNA synthesis screening technology
Multi-donor fund supporting biosecurity prevention priorities
field-building
Supervised Program for Alignment Research (Kairos AI Project): part-time remote three-month research fellowship that added a biosecurity stream in 2026, with projects mentored by Fourth Eon, Johns Hopkins CHS, SecureBio AI, and Pivotal.
Stripe Respiratory Pathogen Fund
regranting
Philanthropic fund supporting built environment biohardening and medical countermeasures
World Bank-hosted multilateral fund financing pandemic prevention, preparedness, and response capacity
UK AI Security Institute: conducts frontier model evaluations for biological, chemical, and cyber misuse risk
biotech
Medical countermeasure development company
Alphabet health technology company with public health surveillance capabilities
Immunology company whose foundation is antibody-based medicines against infectious disease threats, including COVID-19, Ebola, and chronic hepatitis
regranting
Major global health funder supporting medical countermeasures and pandemic preparedness
WHO Hub for Pandemic and Epidemic Intelligence: global collaborative surveillance and epidemic intelligence
Harvard bioengineering institute developing pathogen-resistant materials, diagnostics, and built-environment biodefense
field-building
Early-stage local biosecurity hub running a small-group course on catastrophic biological risks, a Biosecurity Futures lecture series at ETH Zurich, a monthly reading group, and career advising.