Priorities
Eleven interlocking priorities organized under three pillars. Each priority targets a specific layer of the biological risk supply chain, detection surface, or defensive response.
| Pillar | 5-year budget | |
|---|---|---|
| Prevent | 5 priorities | $500M |
| Detect | 2 priorities | $325M |
| Respond | 4 priorities | $1.775B |
| Total | 11 priorities | $2.6B |
* Diagnostics & Testing is a cross-pillar priority that spans both Detect and Respond. Its budget is counted once under Detect and is not double-counted in the total.
Prevent
Stop dangerous capabilities from being acquired or misused
Nucleic Acid Synthesis Screening
Block unauthorized access to dangerous biological materials at the point of nucleic acid synthesis.
Urgent 2027 milestone →
Know Your Customer (KYC)
Ensure that entities accessing dangerous biological tools, services, and materials are legitimate and accountable.
Urgent 2027 milestone →
AIxBio Safeguards
Ensure that AI systems capable of substantially accelerating biological misuse incorporate robust safeguards.
Urgent 2027 milestone →
Research Governance
Institute effective, risk-based oversight for all high-consequence biological research — regardless of funding source — in every jurisdiction that conducts it.
Urgent 2027 milestone →
Threat Disruption, Attribution & Deterrence
Develop capabilities to monitor and disrupt threat groups, identify the origins of biological incidents, and signal that misuse will be detected and attributed.
Urgent 2027 milestone →
Detect
Identify threats that prevention misses
Global Early Warning
Deploy pathogen-agnostic surveillance that can identify any pathogen before it spreads widely.
Urgent 2027 milestone →
Diagnostics & Testing
Ensure any novel pathogen can be identified in patients and populations rapidly, at scale, from the first days of a crisis.
Urgent 2027 milestone →
Respond
Respond faster than the pathogen can spread
Diagnostics & Testing
Ensure any novel pathogen can be identified in patients and populations rapidly, at scale, from the first days of a crisis.
Urgent 2027 milestone →
Essential Workforce Protection
Protect critical infrastructure from any respiratory pandemic, including essential workers who maintain food, water, power, healthcare, and public order.
Urgent 2027 milestone →
Built Environment Biohardening
Transform buildings into pathogen-resistant spaces through improved air filtration, germicidal lighting, and emergency air disinfection measures.
Urgent 2027 milestone →
Rapid Medical Countermeasures
Build the capacity to develop, manufacture, and deploy vaccines and therapeutics in less than 100 days of identifying a new threat.
Urgent 2027 milestone →
Global Response Coordination
Build, exercise, and maintain the public-private partnerships and coordination mechanisms needed to mount an effective response to a catastrophic pandemic.
Urgent 2027 milestone →