2029Scale and enforce
2029 is the scale year. Voluntary systems must become enforceable; local systems must become international; we need to turn promising pilots into durable preparedness infrastructure.
Last updated: October 1, 2026
Suggested philanthropic spend
$595M
Cumulative
$1.455B
Prevent
$115M
Detect
$80M
Respond
$400M
2029 Pillar Objectives
Prevent
- Move from uneven adoption to broad enforceable coverage across synthesis screening, KYC, AIxBio safeguards, and high-risk research governance.
- Expand attribution, monitoring, and deterrence capabilities so that malicious actors face increasing friction, visibility, and accountability.
Detect
- Scale early-warning systems from initial deployment into a genuinely international architecture with meaningful geographic reach and faster response timelines.
Respond
- Expand protective stockpiles, biohardening, MCM readiness, and multinational response exercises so that defensive systems begin to resemble durable infrastructure at national and international scale.
Milestones
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PreventKnow Your Customer (KYC)
Extend KYC to CROs, cloud labs, repositories, reagent suppliers, and AI/bio tools
PreventAIxBio Safeguards
Mandate safeguards for high-risk LLMs, biological AI models, and autonomous AI-lab systems
PreventResearch Governance
Move from pilot research governance to institutionalized oversight, licensing, audit, and institutional adoption frameworks
Require misuse monitoring and threat sharing for high-risk biological services
DetectGlobal Early Warning
Scale pathogen-agnostic surveillance and signal-to-action workflows to major hubs and sentinel sites on six continents
DetectDiagnostics & Testing
Authorize pathogen-agnostic diagnostics and build surge manufacturing capacity for rapid test deployment
Expand PPE stockpiles toward broad essential-workforce coverage and secure surge manufacturing agreements
Begin wider deployment of biohardening technologies through public-building requirements and code pathways
Validate progress toward 100-day MCM capability, distributed manufacturing, and market incentives through exercises
RespondGlobal Response Coordination