2031Maintain defensive advantage
The purpose of these first five years is to establish a durable global biodefense architecture that continues to improve over time.
Last updated: October 1, 2026
Suggested philanthropic spend
$480M
Cumulative
$2.6B
Prevent
$45M
Detect
$55M
Respond
$380M
2031 Pillar Objectives
Prevent
- Sustain high-coverage, high-quality upstream safeguards and keep them current as technologies, markets, and threat actors evolve.
Detect
- Maintain and refine a global pathogen-agnostic early-warning architecture capable of functioning as a permanent layer of defense.
Respond
- Maintain stockpiles, manufacturing readiness, built-environment protections, rapid MCM capability, and coordination systems as permanent components of biodefense readiness.
Milestones
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PreventKnow Your Customer (KYC)
Sustain high KYC compliance across high-risk biological vendors
PreventAIxBio Safeguards
Sustain AI-bio safeguards across frontier LLMs, biological AI models, and autonomous-lab systems
PreventResearch Governance
Reach high-risk research oversight and bio-audit coverage targets
Reach misuse-detection and red-teaming coverage targets across high-risk services
DetectGlobal Early Warning
Sustain and refine the global pathogen-agnostic surveillance and response-trigger architecture
DetectDiagnostics & Testing
Maintain diagnostic readiness: authorized platforms, surge capacity, and exercised deployment
Maintain PPE stockpiles, surge manufacturing, and exercised delivery systems
Continue deployment of pathogen-resistant building measures and maintain public-building response playbooks
Cement distributed manufacturing, market incentives, and public-private partnerships for rapid MCM deployment
RespondGlobal Response Coordination
Institutionalize annual exercises, transparent progress reporting, and specific multinational response workflows
Cross-cutting metrics
- To designFramework for measuring whether defensive capacity is actually outpacing offensive proliferation
Tracked means metric defined and data flowing. To design means metric concept agreed, but instrumentation not yet built.